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SEMO Football 2022 Schedule
| September 3rd (Saturday) | 6:30 PM | @ Iowa State |
| September 10th (Saturday) | 6:00 PM | @ Southern Illinois |
| September 17th (Saturday) | 2:00 PM | vs Nicholls |
| September 24th (Saturday) | 2:00 PM | vs Central Arkansas Bears |
| October 1st (Saturday) | 1:00 PM | @ Lindenwood |
| October 8th (Saturday) | 2:00 PM | vs Tennessee Tech |
| October 15th (Saturday) | OFF | |
| October 22nd (Saturday) | 1:00 PM | @ Nothwestern State |
| October 29th (Saturday) | 1:00 PM | vs Eastern Kentucky |
| November 5th (Saturday) | 5:00 PM | @ Tennessee State |
| November 12th (Saturday) | 2:00 PM | @ Eastern Illinois |
| November 19th (Saturday) | 1:00 PM | vs Murray State |